Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway

TOP1 poisons enhance micronuclei formation mediated by nuclear R-loops and DNA damage

As TOP1 poisoning by CPT has been shown to lead to micronuclei formation [11], we have determined the levels of micronuclei in human SCLC (H209, H889 and DMS114)…